What you can doīefore you start taking Epidiolex, talk with your doctor and pharmacist about all medications you take. This can increase your risk of side effects from other drugs that rely on one or more of these proteins. Your body uses special proteins to transport and break down certain drugs after you take a dose.Įpidiolex can lower the amount of certain proteins in your body or slow down their activity. the organ transplant drugs sirolimus ( Rapamune, others), tacrolimus (Astagraf XL, Prograf), and everolimus ( Afinitor, Zortress).bupropion (Wellbutrin XL, Wellbutrin SR).Interaction with drugs affected by certain proteins in your bodyĮpidiolex interacts with drugs that are affected by certain proteins in your body. Your doctor may decide to increase your Epidiolex dosage if you need to take it with a drug that causes the interaction described above. They can check to see whether any interact with Epidiolex. What you can doīefore you start taking Epidiolex, tell your doctor and pharmacist about all medications you take. This means your body will break down Epidiolex faster, and there may not be enough of the drug in your system for it to work properly. Taking certain drugs increases the level of these enzymes in your body. When you take a dose of Epidiolex, CYP3A4 and CYP2C19 enzymes in your body break down the drug and help remove it from your system. If you take Epidiolex with a drug that increases the activity of the CYP3A4 or CYP2C19 enzymes, Epidiolex may be less effective. the seizure drugs phenytoin (Dilantin) and carbamazepine (Tegretol, others).Interaction with drugs that affect certain enzymes in your bodyĮpidiolex interacts with medications that increase the activity of specific enzymes (proteins) in your body called CYP3A4 and CYP2C19.Įxamples of drugs that increase the activity of these enzymes include: have you stop taking Epidiolex or the valproic acid drug.adjust your dosage of Epidiolex or the valproic acid drug.If these tests show that you have a problem with your liver, your doctor may either:
This includes using blood tests to check your liver enzyme levels. If your doctor determines you’ll take Epidiolex with a valproic acid drug, they’ll closely monitor your liver function during treatment. Combining these medications raises the risk of these side effects. (With off-label use, doctors prescribe a drug for a purpose other than what it’s approved for.)Įxamples of valproic acid and similar medications include:īoth Epidiolex and valproic acid drugs can cause liver problems, including liver damage and an increase in liver enzyme levels. They’re also prescribed off-label to treat other conditions, including certain mental health conditions. These medications are prescribed to manage seizures in certain situations. Interaction with valproic acid and drugs similar to itĮpidiolex interacts with valproic acid and drugs similar to it. Learn more about certain drug interactions that can occur with Epidiolex.
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